Recent studies of the pathogenesis of malaria have shown that parasite triggered red blood cell rosette formation is associated with the severity of clinical disease and malaria 4,5. In the century since the discovery of the abo blood groups, numerous associations between abo groups and disease have been noted. Plasmodium malaria and abo blood group among blood donors in. The abo blood group system is the most important blood group system in clinical practice. Blood group phenotypes a and b are risk factors for. Correlation between h blood group antigen and plasmodium. Host genetic adaptations to plasmodium falciparum suggest new potential malaria treatment strategies. Falciparuminfected individuals were categorized as severe malaria and uncomplicated malaria. Abo blood group system, the classification of human blood based on the inherited properties of red blood cells erythrocytes as determined by the presence or absence of the antigens a and b, which are carried on the surface of the red cells. However, several studies undertaken have been unable to link abo blood groups to the incidence of malaria or to the repeat attacks of malaria 2,3. Individuals with blood group a have been found to be highly susceptible to falciparum malaria whereas blood group.
Certain abo blood group is thought to be protective of severe malaria. Transmission of malaria by blood transfusion remains a significant public health problem in the malaria endemic regions like nigeria. Controls have a higher prevalence of group o, and cases have a higher prevalence of non. Consequently, a high risk of transfusiontransmitted malaria persists. Abo blood groups and severity to plasmodium falciparum. Association of abo blood group and plasmodium falciparum. This study was undertaken to investigate the abilities of different blood group erythrocytes to support in vitro growth of p. These antigens may be proteins, carbohydrates, glycoproteins, or glycolipids, depending on the blood group system.
Of the 276 students examined for malaria infection, 27 were found positive 9. This study therefore was to investigate plasmodium malaria and abo blood group among blood. Of 17 blood group o malaria cases, 10 were having mild malaria while 05 had moderate and 02 had severe malaria. Hence, there was a statistically significant relation between complicated mixed malaria cases and blood groups x. Persons may thus have type a, type b, type o, or type ab blood. The abo blood group system is used to denote the presence of one, both, or neither of the a and b antigens on erythrocytes. The abo blood groups consist of a, b and h carbohydrate antigens which can regulate protein activities during infection and antibodies against these antigens. We explored effects of abo blood group on asymptomatic, uncomplicated and placental falciparum. In the other blood groups, it was observed that groups mnss. Although the human genome has been remarkably altered by. In human blood transfusions it is the most important of the 36 different blood type or group classification systems currently recognized. Priyanka barua, lecturer, department of zoology, university of dhaka, bangladesh, email.
There is increasing evidence that plasmodium falciparum malaria is influenced by abo blood group but the extent of association between both is yet to be well defined. Group o is the most common blood group in turkey and persia. Malaria parasitaemia was determined by microscopy of giemsastained. The abo blood group system and plasmodium falciparum malaria. The plasmodium parasite has established a close relationship between itself and. Some of these antigens are also present on the surface of other types of cells of. It has long been known that people with blood type o.
B abo distributions among the cases severe or fatal malaria are significantly different from that observed in healthy adult ugandan blood donors. Research open access association of abo blood group with. Abo blood group system an overview sciencedirect topics. A total of 29 human blood group systems are now recognized by the. Variations in reports on the association of abo blood groups and disease progression of. Studies have reported association of abo blood group to resistance, susceptibility, and severity of p. Pdf the study was conducted in a period from march to july 20 in 3 areas in sudan khartoum, al genaid and singa. There is also a hypothesis that plasmodium falciparum p. There has been growing evidence that abo blood group antigens influence susceptibility and resistance to parasitaemia. In 200 malaria positive patients, blood group analysis was done. Of the 276 students examined for malaria infection, 27 were. Malaria has been a major selective force on the human population, and several erythrocyte polymorphisms have evolved that confer resistance to severe malaria. Pdf plasmodium malaria and abo blood group among blood. Except for blood group ab individuals, of which none were infected, malaria infection did not vary among blood groups.
The relationship between plasmodium falciparum and abo blood groups has been studied for many years. The present findings indicate that individuals of blood groups a, b and ab are more susceptible to p. Malaria is a common transfusiontransmissible infection. Abo blood groups and severity to plasmodium falciparum malaria infections barua p department of zoology, university of dhaka, bangladesh corresponding author. No significant differences were found between the presence of malaria infection and abo antigens. A blood type also called a blood group is a classification of blood, based on the presence and absence of antibodies and inherited antigenic substances on the surface of red blood cells rbcs. Transmission of malaria by blood transfusion remains a significant public health problem in the malaria endemic regions like ghana. The link between abo blood groups and the incidence of malaria parasitaemia or immunity to malaria is still unclear akinboye and ogunrinade 1987. The results showed high prevalence of blood group b in both mild n 110 and. Aborhesus blood group systems and malaria prevalence. Plasmodium falciparum rosetting, a parasite virulence phenotype associated with severe malaria, is reduced in blood group o erythrocytes compared with groups a, b, and ab, but the contribution of the abo blood group system to protection against severe malaria has received little attention. A total of 269 febrile outpatients who visited dore bafeno health center, southern ethiopia, were examined for malaria and also tested for abo blood groups in. They support the hypothesis that otype alleles have been evolutionarily selected in areas with high incidences of malarial infection and suggest that rifins may contribute to the varying global distribution of abo blood groups by selecting preferentially for group o. Some of these studies reported significant associations, suggesting that abo blood groups.
There is increasing evidence that the abo blood group phenotypes modulates plasmodium falciparum rosetting and may influence the clinical manifestation of severe malaria. Determination of the various aborh blood group distributions and their association with malaria infection has paramount importance in the context of transfusion medicine and malaria control. Pdf association of asymptomatic malaria and abo blood. Assessing aborh blood group frequency and association. Cheesbrough m 2005 district laboratory manual for tropical countries. Determining the prevalence of malaria parasitaemia among asymptomatic individuals and its association with abo blood grouping could be a step to further studies to understand the immunity of malaria. In clinical practice, abo is the most important system for blood group compatibility. Whether blood group phenotypes are associated with risk of severe falciparum malaria in odisha, we analyzed 343 adult malaria patients. The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the abo blood groups. Influence of abo blood groups in malaria infected pregnant. Most subsaharan africans are duffy blood group negative because of. Association of asymptomatic malaria and abo blood group. Although this therapy helps to save human lives, blood can nonetheless be a dreadful vehicle for the transmission of some infectious.
Among complicated mixed malaria cases, 4 cases had blood group a, 2 cases had blood group ab and 1 case had blood group o. Percentage distribution of the abo blood group types in the three study categories of the 70 blood samples examined in the severe malaria category, there were 25 35. Abo blood group, parasite rosetting and malaria susceptibility. The abo blood group and plasmodium falciparum malaria in. Sri lanka 12, mali 11, and ethiopia 1, while a significant association has also been. How blood group o protects against malaria sciencedaily. Among the uncomplicated malaria cases, 42 30% were of blood group a, 23 16. Prevalence of malaria parasitaemia and its association. Plasmodium falciparum rosetting, a parasite virulence phenotype associated with severe malaria, is reduced in blood group o erythrocytes compared with groups a, b, and ab, but the contribution of the abo blood group system to protection. No signifiant correlation was present between blood groups and distribution of complicated cases, and between complicated falciparum cases and blood groups. Pdf no association of phenotypic abo blood group and.
Seven cases of mixed malaria had blood group a and o. The results showed that blood group a was associated with a higher risk for acquiring covid19 compared with nona blood groups, whereas blood group o was associated with a lower risk for the infection compared with nono blood groups. Large numbers of severe malaria cases were also reported among blood group a individuals11. In the indian scenario, the literature relating to malaria and the blood groups are sparse and have mixed results. Malaria clinical outcomes vary by erythrocyte characteristics, including abo blood group, but the effect of abo blood group on asymptomatic, uncomplicated and placental plasmodium falciparum p. The prevalence of malaria parasitaemia and predisposition. Thakur and verma8 in their study, concluded that abo blood groups do not show differentable 1. Occurrence of plasmodium falciparum malaria associated. Nevertheless, further in depth studies are required to clearly establish the role that abo blood group plays in p. Pdf plasmodium parasitaemia and blood groups among blood. A ll the manifestations of malarial illness are caused by the infection of the red blood cells by the asexual forms of the malaria parasite and the involvement of the red cells makes malaria a potentially multisystem disease, as every organ of the body is reached by the blood. One such gene that is selected for by malaria is the abo blood group gene which has three alleles namely, a, b and o, coding for different types of agglutinogens attached to the surface of red blood cells rbcs and hence determining an individuals blood group. Some studies have suggested that abo blood groups have an impact on the. However, other studies have reported variable associations between malaria infection and abo blood groups 12,19,21,26.
We explored effects of abo blood group on asymptomatic, uncomplicated and placental falciparum infection in the published literature. Abo blood group, parasite rosetting and malaria susceptibility rosetting is characterized by the binding of p. Two drops of whole blood were placed in two different places of a greasefree clean glass slide on which a few drops of anti. Is there a relation between abo blood group and malaria. There was low percentage of blood group o patients in the severe malaria category than in either uncomplicated malaria or healthy controls. Relationship between abo blood groups and malaria with. Silas a ufelle 1, kenechukwu c onyekwelu 2, joy e ikekpeazu 2, richard c ezeh 3, emmanuel a esom 4, uzoamaka a okoli2 1department of medical laboratory sciences, college of medicine, university of nigeria enugu campus, nigeria 2department of medical biochemistry, college of medicine, university. Research article relative susceptibilities of abo blood. Malaria is a disease associated with high morbidity and mortality especially among children and other high risk groups. The abo blood group and plasmodium falciparum malaria in awash, metehara and ziway areas, ethiopia article pdf available in malaria journal 91. Abo blood groups and secretor character in rheumatic carditis.
Influence of abo blood groups in malaria infected pregnant women in enugu, southeast, nigeria. The abo blood group system is arguably the best known, and yet the most functionally mysterious, genetic polymorphism in humans. Guidance manual abo and rh blood grouping document id no. Abo blood groups and malaria related clinical outcome. In fact, group a is found in highest frequency in scandinavia, greenland, and the. Pdf abo blood groups and malaria related clinical outcome. In other reports, the abo blood group pattern differed even if blood group o was most common 19 20 21 cserti and dzik 22, a distribution pattern of blood group o followed by a is characteristic for african endemic for malaria. Association of the abo blood groups with falciparum. This study was aimed at determining the prevalence of parasitaemia in blood donors and the association between blood group antigens and parasitaemia. Relationship between the abo blood group and the covid19. Pdf malaria infection and its relation to abo blood grouping. Table 6 shows distribution of abo blood group in relation to severity of malaria. Relationship between abo blood groups and malaria with clinical. Effect of abo blood group on asymptomatic, uncomplicated.
A mismatch very rare in modern medicine in this, or any other serotype, can cause a potentially fatal adverse reaction after a. A total of 2095 patients with fever were tested for malaria and classified according to abo blood groups. A number of studies were conducted to investigate the association between abo blood group system and some disease conditions. No association of phenotypic abo blood group and malaria during pregnancy. The abo blood group and plasmodium falciparum malaria in awash, metehara and ziway areas, ethiopia. The most striking blood group association is of the duffy blood group with susceptibility to p. Facility based crosssectional study was conducted from february to june, 2015, to assess aborh blood groups distribution and their association with asymptomatic malaria. Research article assessing aborh blood group frequency. This parasite uses the duffy blood group antigen as the receptor to invade erythrocytes. Severe malaria was further clinically phenotyped into cerebral malaria, noncerebral severe malaria and multiorgan dysfunction.
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